Improve clinical decision support with information on. PEGs have a long history of gastroenterology: PEG 3350 is a common over-the-counter osmotic laxative used to relieve occasional constipation.8 PEG 3350 is also used for cleansing of the colon in preparation for colonoscopy in adults.5, The rationale of using PEG in gastroenterology is due to the physical properties of the compound: its potent water-binding capacity, negligible intestinal absorption with increasing molecular mass, lack of significant toxicity, and limited intestinal enzymatic degradation or bacterial metabolism all make PEG a useful therapeutic agent for the treatment of occasional constipation and bowel cleansing for preparation in colonoscopy.1, Polyethylene glycol is indicated for use as an over-the-counter osmotic laxative to relieve occasional constipation.8 When used in combination with sodium ascorbate, sodium sulfate, ascorbic acid, sodium chloride and potassium chloride, it is used for cleansing of the colon in preparation for colonoscopy in adults.5, The osmotic effect of PEG produces a copious watery diarrhea. WebMechanism of action. Simethicone is a surfactant that decreases the surface tension of gas bubbles in the gastrointestinal tract, Rattanasiri S: Improving quality of colonoscopy by adding simethicone to sodium phosphate bowel preparation. Activated charcoal in addition to a cathartic agent should be administered. Sodium bicarbonate is a compound used for the symptomatic treatment of heartburn, acid indigestion, and upset stomach as well as the treatment of metabolic acidosis associated with conditions such as severe renal disease and circulatory insufficiency due to shock. The therapeutic efficacy of Sodium phosphate, dibasic, unspecified form can be decreased when used in combination with Meclizine. Sennidins A and B are further metabolized to rheinanthrone Rheinanthrone by gut bacteria using beta-glucosidase2. The metabolism of Oxybutynin can be increased when combined with Abatacept. [, Werle M: Natural and synthetic polymers as inhibitors of drug efflux pumps. A synthetic morphinan analgesic with narcotic antagonist action. Thus, the drug can be used for therapeutic advantages to increase concentrations of certain -lactam antibiotics in the treatment of gonorrhea, neurosyphilis, or pelvic inflammatory disease (PID). Increased risk of aplastic anemia, leukopenia and hemolytic anemia. Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. U.S. Patent US3984527, issued August, 1922. [, Commiskey S, Fan LW, Ho IK, Rockhold RW: Butorphanol: effects of a prototypical agonist-antagonist analgesic on kappa-opioid receptors. It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. As an over-the-counter laxative, the OTC product does not contain any salts that can be absorbed.4 In a study involving healthy subjects, PEG 3350 had negligible effects on colonic fluid absorption or with the ability of the colonic mucosa to generate and sustain steep electrochemical gradients.3, Osmotic laxatives contain substances that are poorly absorbable and draw water into the lumen of the bowel.9 Polyethylene glycol functions is an osmotic laxative that causes increased water retention in the lumen of the colon by binding to water molecules, thereby producing loose stools.4,5, Following a two-day split-dosing regimen of an oral suspension containing 140 grams of PEG 3350 in healthy subjects, the mean Cmax was 2.7 mcg/mL and the mean Tmax was 3 hours.5 Typically, polyethylene glycols with a high molecular weight are poorly absorbed from the gastrointestinal tract following oral administration.2,3, Following a two-day split-dosing regimen of an oral suspension containing 140 grams of PEG 3350 in healthy subjects, the mean volume of distribution was 48,481 L.5. Patients are also advised not to use potassium-containing salt replacements. Ther Clin Risk Manag. [, Levraut J, Giunti C, Ciebiera JP, de Sousa G, Ramhani R, Payan P, Grimaud D: Initial effect of sodium bicarbonate on intracellular pH depends on the extracellular nonbicarbonate buffering capacity. Epub 2003 Feb 12. Simethicone is a surfactant that decreases the surface tension of gas bubbles in the gastrointestinal tract, Rattanasiri S: Improving quality of colonoscopy by adding simethicone to sodium phosphate bowel preparation. 2001 May;86(5):2056-9. [, Oki T, Kageyama A, Takagi Y, Uchida S, Yamada S: Comparative evaluation of central muscarinic receptor binding activity by oxybutynin, tolterodine and darifenacin used to treat overactive bladder. The therapeutic efficacy of Sodium phosphate, monobasic, unspecified form can be decreased when used in combination with Ipratropium. J Biol Chem. 2003 Sep;285(3):F524-31. Passive transport: membrane channels. Fluconazole is a very selective inhibitor of fungal cytochrome P450 dependent enzyme lanosterol 14--demethylase. The risk or severity of adverse effects can be increased when Butorphanol is combined with Alosetron. U.S. Patent US20040006243, issued January 08, 2004. 2006 Mar;2(1):19-24. The therapeutic efficacy of Cyanocobalamin can be decreased when used in combination with Tedizolid phosphate. The risk or severity of adverse effects can be increased when Butorphanol is combined with Almotriptan. WebAlendronic acid, sold under the brand name Fosamax among others, is a bisphosphonate medication used to treat osteoporosis and Paget's disease of bone. Drug created at July 08, 2007 16:59 / Updated at December 10, 2022 03:33, Structured drug data for data science & ML, Clinical intelligence tool for your software, Search for drug interactions with our API, Get drug allergy and cross sensitivities info. [, Yamamura H, Ugawa S, Ueda T, Shimada S: Evans blue is a specific antagonist of the human epithelial Na+ channel delta-subunit. Drug Metab Dispos. [, Yaich M, Popon M, Medard Y, Aigrain EJ: In-vitro cytochrome P450 dependent metabolism of oxybutynin to N-deethyloxybutynin in humans. Web$5000 awarded annually by the Society of Biological Psychiatry! 2005 Nov 3;438(7064):6. Sodium hydroxide is a highly caustic base and alkali that decomposes proteins at ordinary ambient temperatures and may cause severe chemical StatPearls Publishing. J Pharm Biomed Anal. Acromegaly is a disorder caused by excess growth hormone (GH), increasing the growth of body tissues and causing metabolic dysfunction. A decrease in aquaporin 3 expression likely produces the laxative effect by restricting water reabsorption by the large intestine thereby increasing fecal water content2. 2019 Jan;38(1):200-207. doi: 10.1002/nau.23828. Plasma half-life varies from 6 to 9 hours. This information should not be interpreted without the help of a healthcare provider. [, Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. 2001 Feb;18(2):171-6. Easily compare up to 40 drugs with our drug interaction checker. Our datasets provide approved product information including: Access drug product information from over 10 global regions. [, Jung KY, Takeda M, Kim DK, Tojo A, Narikawa S, Yoo BS, Hosoyamada M, Cha SH, Sekine T, Endou H: Characterization of ochratoxin A transport by human organic anion transporters. [, Rius M, Nies AT, Hummel-Eisenbeiss J, Jedlitschky G, Keppler D: Cotransport of reduced glutathione with bile salts by MRP4 (ABCC4) localized to the basolateral hepatocyte membrane. Easily compare up to 40 drugs with our drug interaction checker. Jennifer Dwyer; Chad A. LaGrange (2019). [, Serrani RE, Mujica G, Gioia IA, Corchs JL: Neonatal red blood cells: amiloride-insensitive Na+-H+ transport isoform would express Na+-Li+ exchange. Improve clinical decision support with information on. 2009 Nov;276(21):6258-70. doi: 10.1111/j.1742-4658.2009.07334.x. It is also a urinary alkalizer, increasing the excretion of free bicarbonate ions in the urine, thus effectively raising the urinary pH. [, Race JE, Grassl SM, Williams WJ, Holtzman EJ: Molecular cloning and characterization of two novel human renal organic anion transporters (hOAT1 and hOAT3). 2000;25(3-4):71-4. Sodium phosphate, monobasic may increase the hyperkalemic activities of Fluconazole. Epub 2011 May 24. 1988;35(5):515-20. doi: 10.1007/bf00558247. sodium phosphate rectal, sodium acid phosphate. Biochem Biophys Res Commun. WebThe NDC Code 63323-165-01 is assigned to a package of 25 vial in 1 tray > 1 ml in 1 vial (63323-165-02) of Dexamethasone Sodium Phosphate, a human prescription drug labeled by Fresenius Kabi Usa, Llc. Avoid life-threatening adverse drug events & improve clinical decision support. WebColistin, also known as polymyxin E, is an antibiotic medication used as a last-resort treatment for multidrug-resistant Gram-negative infections including pneumonia. Probenecid may also reduce plasma binding of urate and inhibit renal secretion of uric acid at subtherapeutic concentrations. 1985 Mar 15;34(6):747-54. It typically begins working in minutes when given by rectum and within twelve hours when given by mouthLabel. sodium phosphate rectal, sodium acid phosphate. [, Ma W, Hui H, Pelegrin P, Surprenant A: Pharmacological characterization of pannexin-1 currents expressed in mammalian cells. Hypertension. [, Ito Y, Oyunzul L, Yoshida A, Fujino T, Noguchi Y, Yuyama H, Ohtake A, Suzuki M, Sasamata M, Matsui M, Yamada S: Comparison of muscarinic receptor selectivity of solifenacin and oxybutynin in the bladder and submandibular gland of muscarinic receptor knockout mice. Due to its potassium-sparing capacities, hyperkalemia (high blood potassium levels) are occasionally observed in patients taking amiloride. The risk or severity of adverse effects can be increased when Polyethylene glycol is combined with Alloin. Acromegaly is a disorder caused by excess growth hormone (GH), increasing the growth of body tissues and causing metabolic dysfunction. Avoid life-threatening adverse drug events & improve clinical decision support. Contraindicated. [, Aprile S, Canavesi R, Matucci R, Bellucci C, Del Grosso E, Grosa G: New insights in the metabolism of oxybutynin: evidence of N-oxidation of propargylamine moiety and rearrangement to enaminoketone. Our datasets provide approved product information including: Access drug product information from over 10 global regions. Epub 2008 Jul 2. 2006 Dec;5(12):993-6. The medication is taken by mouth or via the rectumLabel. WebMechanism of action. 2002 Mar-Apr;15 Suppl 5:S32-40. [, Planes C, Leyvraz C, Uchida T, Angelova MA, Vuagniaux G, Hummler E, Matthay M, Clerici C, Rossier B: In vitro and in vivo regulation of transepithelial lung alveolar sodium transport by serine proteases. 1990;15(2):86-93. J Biol Chem. Crit Care Med. J Biol Chem. Masui. Kit; Powder, for solution; Tablet, delayed release, Endofalk Pulver zur Herstellung einer Lsung zum Einnehmen, Kit; powder, for solution; tablet, delayed release, Cream; kit; powder, for solution; tablet, coated. [, Roderick P, Willis NS, Blakeley S, Jones C, Tomson C: Correction of chronic metabolic acidosis for chronic kidney disease patients. Monkovic, I. and Conway, T.T. Mechanism of action. WebProduction. 2005;107(1):77-86. A note on angioedema and anticholinergic effects, Symptoms of angioedema may occur with oxybutynin therapy. Epub 2007 Oct 2. Serious - Use Alternative (2) Epub 2005 Sep 27. The oral LD50 of amiloride hydrochloride (calculated as the base) is 56 mg/kg in mice and 36 to 85 mg/kg in rats, depending on the strain. The therapeutic efficacy of Sodium phosphate, dibasic, unspecified form can be decreased when used in combination with Butorphanol. 2002 Aug 19;1591(1-3):99-107. Passive transport: membrane channels. Epub 2014 Oct 20. Biochim Biophys Acta. 2003 Jun;55(2):131-40. WebMechanism of action. WebIndication Associated Conditions Associated Therapies Contraindications & Blackbox Warnings Pharmacodynamics Mechanism of action Absorption Volume of distribution Protein binding U Glyceraldehyde-3-phosphate dehydrogenase, testis-specific: (2.94 mg / g) + Potassium Iodide (0.0088 mg / g) + Selenium (11.76 mcg / g) + Sodium Azithromycin is a broad-spectrum macrolide antibiotic with a long half-life and a high degree of tissue penetration 3.It was initially approved by the FDA in 1991 4.. [, Shin HJ, Takeda M, Enomoto A, Fujimura M, Miyazaki H, Anzai N, Endou H: Interactions of urate transporter URAT1 in human kidney with uricosuric drugs. Probenecid inhibits the tubular reabsorption of urate, thus increasing the urinary excretion of uric acid and decreasing serum urate levels. A review of its pharmacodynamic and pharmacokinetic properties, and its therapeutic use in detrusor instability. [, Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Epub 2004 May 27. 5,8 Gentamicin is effective against both Amiloride works by inhibiting sodium reabsorption in the distal convoluted tubules and collecting ducts in the kidneys by binding to the amiloride-sensitive sodium channels. [, McCrery RJ, Appell RA: Oxybutynin: an overview of the available formulations. Eur J Pharmacol. The therapeutic efficacy of Polyethylene glycol can be decreased when used in combination with Aluminium phosphate. WebMechanism of action. [, Chen ZS, Lee K, Walther S, Raftogianis RB, Kuwano M, Zeng H, Kruh GD: Analysis of methotrexate and folate transport by multidrug resistance protein 4 (ABCC4): MRP4 is a component of the methotrexate efflux system. 2000 Aug;83(3):375-83. Int J Mol Med. The absence of an interaction does not necessarily mean no interactions exist. 2000 Jun;105(11):1651-8. 2015 Feb;23(2):180-90. doi: 10.3109/1061186X.2014.971328. [, Yamamura H, Ugawa S, Ueda T, Nagao M, Shimada S: Icilin activates the delta-subunit of the human epithelial Na+ channel. Pharmacogenetics. 2001 Sep;281(3):F454-68. Avoid life-threatening adverse drug events & improve clinical decision support. 2003 Apr 25;278(17):15023-34. The serum concentration of Alendronic acid can be decreased when it is combined with Sodium bicarbonate. sodium phosphate rectal, sodium acid phosphate. Am J Physiol Gastrointest Liver Physiol. Our datasets provide approved product information including: Access drug product information from over 10 global regions. The therapeutic efficacy of Sodium phosphate, dibasic, unspecified form can be decreased when used in combination with Butorphanol. 9 It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to cidoxepin.Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. Epub 2004 Oct 25. Epub 2004 Feb 4. The sodium-potassium pump sets the membrane potential of the neuron by keeping the concentrations of Na + and K + at constant Articles report on outcomes research, prospective studies, and controlled trials of new endoscopic instruments and treatment methods. [. 2006 Jul 14;281(28):19220-32. World J Gastroenterol. [, Issandou M, Grand-Perret T: Multidrug resistance P-glycoprotein is not involved in cholesterol esterification. 1999 Jun 1;59(11):2532-5. 2006 Jan;316(1):279-88. The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Aceclofenac is combined with Amiloride. WebIndication Associated Conditions Associated Therapies Contraindications & Blackbox Warnings Pharmacodynamics Mechanism of action Absorption Volume of distribution Protein binding U Glyceraldehyde-3-phosphate dehydrogenase, testis-specific: (2.94 mg / g) + Potassium Iodide (0.0088 mg / g) + Selenium (11.76 mcg / g) + Sodium [, Ugawa S, Yamamoto T, Ueda T, Ishida Y, Inagaki A, Nishigaki M, Shimada S: Amiloride-insensitive currents of the acid-sensing ion channel-2a (ASIC2a)/ASIC2b heteromeric sour-taste receptor channel. Fruits and vegetables can be rich Rheinanthrone Rheinanthrone is absorbed into systemic circulation where 2.6% is metabolized to rhein Rhein and sennidins A and B via oxidation4,7,2. WebProduction. [, Kurtz I, Petrasek D, Tatishchev S: Molecular mechanisms of electrogenic sodium bicarbonate cotransport: structural and equilibrium thermodynamic considerations. Improve clinical decision support with information on. 3 Dexamethasone's duration of action varies depending on the route. Acromegaly is a disorder caused by excess growth hormone (GH), increasing the growth of body tissues and causing metabolic dysfunction. J Pediatr Endocrinol Metab. WebMechanism of action. Electrolytes (including serum potassium, calcium, chloride, magnesium, phosphate, sodium), acid/base balance; renal function; cardiac monitor (if intermittent infusion or potassium infusion rates 0.5 mEq/kg/hour in children or >10 mEq/hour in adults); to assess adequate replacement, repeat serum potassium level 2 to 4 hours after dose; 2015;2015:578107. doi: 10.1155/2015/578107. The therapeutic efficacy of Sodium phosphate, dibasic, unspecified form can be decreased when used in combination with Butorphanol. Epub 2009 Mar 25. Epub 2005 Jan 28. Anal Biochem. The normal blood sodium level is 135 to 145 milliequivalents/liter (mEq/L). World J Gastroenterol. [, de Witte P, Lemli J: Metabolism of 14C-rhein and 14C-rhein anthrone in rats. J Pharmacol Exp Ther. The bioavailability of Beclomethasone dipropionate can be decreased when combined with Sodium bicarbonate. Amiloride exerts its potassium sparing effect through the inhibition of sodium reabsorption at the distal convoluted tubule, cortical collecting tubule and collecting duct; this decreases the net negative potential of the tubular lumen and reduces both potassium and hydrogen secretion and their subsequent excretion. 2004 Feb 27;279(9):8428-40. The therapeutic efficacy of Polyethylene glycol can be decreased when used in combination with Amiodarone. [, Kamide K, Tanaka C, Takiuchi S, Miwa Y, Yoshii M, Horio T, Kawano Y, Miyata T: Six missense mutations of the epithelial sodium channel beta and gamma subunits in Japanese hypertensives. The therapeutic efficacy of Sodium phosphate, dibasic, unspecified form can be decreased when used in combination with Oxybutynin. Xenobiotica. Sodium bicarbonate can cause a decrease in the absorption of Acetophenazine resulting in a reduced serum concentration and potentially a decrease in efficacy. The therapeutic efficacy of Sodium phosphate, monobasic, unspecified form can be decreased when used in combination with [, Hong J, Lambert JD, Lee SH, Sinko PJ, Yang CS: Involvement of multidrug resistance-associated proteins in regulating cellular levels of (-)-epigallocatechin-3-gallate and its methyl metabolites. If you believe you are experiencing an interaction, contact a healthcare provider immediately. 1 It has a very long half-life compared to other cephalosporins and is high penetrable into the meninges 1, eyes 9, and inner ear 6.Ceftriaxone has broader and stronger gram-negative coverage then first or 2012 Mar;25(1):12-9. doi: 10.1055/s-0032-1301754. [, Ji HL, Su XF, Kedar S, Li J, Barbry P, Smith PR, Matalon S, Benos DJ: Delta-subunit confers novel biophysical features to alpha beta gamma-human epithelial sodium channel (ENaC) via a physical interaction. 2010;25(2):163-9. [, Payen L, Delugin L, Courtois A, Trinquart Y, Guillouzo A, Fardel O: Reversal of MRP-mediated multidrug resistance in human lung cancer cells by the antiprogestatin drug RU486. Build, train, & validate predictive machine-learning models with structured datasets. This information should not be interpreted without the help of a healthcare provider. The therapeutic efficacy of Sodium phosphate, monobasic, unspecified form can be decreased when used in combination with Escitalopram. Print 2016 Oct. [, Zelcer N, Saeki T, Reid G, Beijnen JH, Borst P: Characterization of drug transport by the human multidrug resistance protein 3 (ABCC3). [, Devineni D, Vaccaro N, Murphy J, Curtin C, Mamidi RN, Weiner S, Wang SS, Ariyawansa J, Stieltjes H, Wajs E, Di Prospero NA, Rothenberg P: Effects of rifampin, cyclosporine A, and probenecid on the pharmacokinetic profile of canagliflozin, a sodium glucose co-transporter 2 inhibitor, in healthy participants. Epub 2004 Nov 10. Probenecid is a medication used to treat gouty arthritis, tophaceous gout, and hyperuricemia. 2007 Feb;177(2):766-70. Cochrane Database Syst Rev. The metabolism of Acalabrutinib can be decreased when combined with Oxybutynin. 2000 Jun 1;1466(1-2):315-27. This information should not be interpreted without the help of a healthcare provider. WebMechanism of action. The metabolism of Abemaciclib can be decreased when combined with Oxybutynin. If angioedema is suspected, discontinue oxybutynin immediately and provide appropriate medical treatment.14 In addition, anticholinergic effects may occur with the administration of this drug. Ceftriaxone is a broad-spectrum third-generation cephalosporin antibiotic. Avoid life-threatening adverse drug events & improve clinical decision support. Sodium phosphate, monobasic: Sodium phosphate, monobasic may increase the hyperkalemic activities of Labetalol. J Biol Chem. 2008 Jan;196(1):143-55. 2009 Jul 3;284(27):18143-51. doi: 10.1074/jbc.M109.004804. Overactive bladder (OAB) is a common condition negatively impacting the lives of millions of patients worldwide. 1999 Dec;56(6):2128-36. [, Youngblood GL, Sweet DH: Identification and functional assessment of the novel murine organic anion transporter Oat5 (Slc22a19) expressed in kidney. There is limited information on the protein binding profile of polyethylene glycols. The risk or severity of adverse effects can be increased when Butorphanol is combined with 1,2-Benzodiazepine. Sodium phosphate, monobasic: Sodium phosphate, monobasic may increase the hyperkalemic activities of Sotalol. Rheinanthrone Rheinanthrone also stimulates peristalsis in the large intestine although the mechanism behind this effect is unknown6. The therapeutic efficacy of Sodium phosphate, dibasic, unspecified form can be decreased when used in combination with Meclizine. WebUrea, also known as carbamide, is an organic compound with chemical formula CO(NH 2) 2.This amide has two amino groups ( NH 2) joined by a carbonyl functional group (C(=O)). J Pharmacol Exp Ther. The absence of an interaction does not necessarily mean no interactions exist. [. Many foods are natural sources of benzoic acid, its salts, and its esters. [, Evers R, de Haas M, Sparidans R, Beijnen J, Wielinga PR, Lankelma J, Borst P: Vinblastine and sulfinpyrazone export by the multidrug resistance protein MRP2 is associated with glutathione export. The active metabolite of sennosides is excreted in breast milk, though there are no reports of the laxitive effect in breast fed babies12. WebThe NDC Code 63323-165-01 is assigned to a package of 25 vial in 1 tray > 1 ml in 1 vial (63323-165-02) of Dexamethasone Sodium Phosphate, a human prescription drug labeled by Fresenius Kabi Usa, Llc. The normal blood sodium level is 135 to 145 milliequivalents/liter (mEq/L). Am J Physiol Renal Physiol. Amiloride is not an aldosterone antagonist and its effects are seen even in the absence of aldosterone. Hypertens Res. J Membr Biol. WebMechanism of action. 2005 Feb;67(2):545-57. The absence of an interaction does not necessarily mean no interactions exist. Either increases toxicity of the other. 2011 Aug;72(2):235-46. doi: 10.1111/j.1365-2125.2011.03961.x. [, Narita M, Feng Y, Makimura M, Hoskins B, Ho IK: Repeated administration of opioids alters characteristics of membrane-bound phorbol ester binding in rat brain. J Pharmacol Exp Ther. J Biol Chem. Biochem Biophys Res Commun. Improve clinical decision support with information on. [, Frieling T, Rupprecht C, Schemann M: Rhein stimulates electrogenic chloride secretion by activation of submucosal neurons in guinea pig colon. 2000 Jan 28;112(2):53-60. The therapeutic efficacy of Sodium phosphate, monobasic, unspecified form can be decreased when used in combination with Escitalopram. WebMechanism of action. Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals Inc. FEBS J. AAPS J. Further indicated in the treatment of certain drug intoxications, including barbiturates (where dissociation of the barbiturateprotein complex is desired), in poisoning by salicylates or methyl alcohol and in hemolytic reactions requiring alkalinization of the urine to diminish nephrotoxicity of blood pigments. Sodium phosphate, monobasic: Sodium phosphate, monobasic may increase the hyperkalemic activities of Labetalol. 1999 Jan 15;274(3):1519-24. 1989 Oct;38(10):1293-300. Either increases effects of the other by pharmacodynamic synergism. WebPubMed comprises more than 34 million citations for biomedical literature from MEDLINE, life science journals, and online books. 2012 Mar;25(1):12-9. doi: 10.1055/s-0032-1301754. Sodium phosphate, monobasic: 2001 Nov;18(11):1528-34. Pharmacology. The exact mechanism of action is unknown, but is believed to interact with an opiate receptor site in the CNS (probably in or associated with the limbic system). [, Hashimoto T, Narikawa S, Huang XL, Minematsu T, Usui T, Kamimura H, Endou H: Characterization of the renal tubular transport of zonampanel, a novel alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor antagonist, by human organic anion transporters. Probenecid inhibits the tubular reabsorption of urate, thus increasing the urinary excretion of uric acid and decreasing serum urate levels. [, Bedford laboratories div ben venue laboratories inc, Bristol myers squibb co pharmaceutical research institute, Vivian JA, DeYoung MB, Sumpter TL, Traynor JR, Lewis JW, Woods JH: kappa-Opioid receptor effects of butorphanol in rhesus monkeys. Mechanism of action. Cancer Res. Hyponatremia occurs when your blood sodium level goes below 135 mEq/L. Use our structured and evidence-based datasets to unlock new insights and accelerate drug research. 2009 Jun 28;15(24):3032-7. doi: 10.3748/wjg.15.3032. [, Kennelly MJ: A comparative review of oxybutynin chloride formulations: pharmacokinetics and therapeutic efficacy in overactive bladder. WebMechanism of action. [, Petruska JC, Napaporn J, Johnson RD, Cooper BY: Chemical responsiveness and histochemical phenotype of electrophysiologically classified cells of the adult rat dorsal root ganglion. [, Sugiyama D, Kusuhara H, Shitara Y, Abe T, Meier PJ, Sekine T, Endou H, Suzuki H, Sugiyama Y: Characterization of the efflux transport of 17beta-estradiol-D-17beta-glucuronide from the brain across the blood-brain barrier. Rev Esp Enferm Dig. Contraindicated. [, Takeda M, Tojo A, Sekine T, Hosoyamada M, Kanai Y, Endou H: Role of organic anion transporter 1 (OAT1) in cephaloridine (CER)-induced nephrotoxicity. [, Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Mechanism of action. Fruits and vegetables can be rich NCS HealthCare of KY, Inc dba Vangard Labs, https://www.chemicalbook.com/ChemicalProductProperty_US_CB0178112.aspx, http://www.hmdb.ca/metabolites/HMDB0015195, https://www.chemicalbook.com/ChemicalProductProperty_US_CB2767266.aspx, 4-(Diethylamino)-2-butynyl alpha-phenylcyclohexaneglycolic acid ester, 4-Diethylamino-2-butinyl alpha-cyclohexylmandelat, 4-Diethylamino-2-butynyl alpha-phenylcyclohexaneglycolate, Douchamps J, Derenne F, Stockis A, Gangji D, Juvent M, Herchuelz A: The pharmacokinetics of oxybutynin in man. The therapeutic efficacy of Sodium phosphate, dibasic, unspecified form can be decreased when used in combination with Oxybutynin. The absence of an interaction does not necessarily mean no interactions exist. Xenobiotica. WebPharmacodynamics. 2004 May;27(5):333-8. 2006 Oct;5(10):821-34. [, Hardcastle JD, Wilkins JL: The action of sennosides and related compounds on human colon and rectum. [, Tsuda M, Sekine T, Takeda M, Cha SH, Kanai Y, Kimura M, Endou H: Transport of ochratoxin A by renal multispecific organic anion transporter 1. doi: 10.1371/journal.pone.0020123. WebUpToDate, electronic clinical resource tool for physicians and patients that provides information on Adult Primary Care and Internal Medicine, Allergy and Immunology, Cardiovascular Medicine, Emergency Medicine, Endocrinology and Diabetes, Family Medicine, Gastroenterology and Hepatology, Hematology, Infectious Diseases, The risk or severity of hypotension and CNS depression can be increased when Acetophenazine is combined with Butorphanol. 2009 Nov;41(5):525-34. doi: 10.1165/rcmb.2008-0367OC. 2000 Dec 20;279(2):369-77. [, Jones NG, Slater R, Cadiou H, McNaughton P, McMahon SB: Acid-induced pain and its modulation in humans. Am J Physiol Renal Physiol. WebMechanism of action. InChI=1S/C13H19NO4S/c1-3-9-14(10-4-2)19(17,18)12-7-5-11(6-8-12)13(15)16/h5-8H,3-4,9-10H2,1-2H3,(H,15,16), Use our structured and evidence-based datasets to. 2003 Oct 10;310(1):222-7. Sodium phosphate, monobasic: ; U.S. Patent 3,775,414; November 27,1973; Monkovic, I.,Wong, H. and Lim, G.; U.S. Patent 3,980,641; September 14, 1976; Pachter, IJ., Belleau, B.R. Based on the pharmacological action of the compound, severe diarrhea may be suspected. 1999 Nov;15(1):91-100. 2004 Dec 1;24(48):10974-9. [, Kim KA, Oh SO, Park PW, Park JY: Effect of probenecid on the pharmacokinetics of carbamazepine in healthy subjects. J Pharmacol Exp Ther. Sennosides are not recommended for use in pregnancy due to genotoxic risks associated with chemically similar compounds12. Epub 2009 Sep 24. Probenecid has also been used to treat patients with renal impairment, and, because it reduces the renal tubular excretion of other drugs, has been used as an adjunct to antibacterial therapy. 1,2-Benzodiazepine may increase the central nervous system depressant (CNS depressant) activities of Oxybutynin. The risk or severity of adverse effects can be increased when Sennosides is combined with Alloin. 2016 Dec;108(12):790-806. doi: 10.17235/reed.2016.4571/2016. The therapeutic efficacy of Sodium phosphate, monobasic, unspecified form can be decreased when used in combination with This information should not be interpreted without the help of a healthcare provider. Eur J Pharmacol. The therapeutic efficacy of Polyethylene glycol can be decreased when used in combination with Alfentanil. 2002 Feb 25;768(1):177-88. Merck Frosst Canada & Cie, Merck Frosst Canada & Co. HHS/Program Support Center/Supply Service Center, Butler D: Wartime tactic doubles power of scarce bird-flu drug. J Clin Pharmacol. The Award Committee makes selections from the 10 top-ranking articles published in Biological Psychiatry in the past year. 12,13,14,15,16,17,18,19,20,21 Corticosteroids have a wide therapeutic window as patients may require doses that are multiples of what the 2000 May 1;52(1):17-20. Drug created at February 10, 2016 16:40 / Updated at December 10, 2022 03:33, Structured drug data for data science & ML, Clinical intelligence tool for your software, Search for drug interactions with our API, Get drug allergy and cross sensitivities info. With structured adverse effects data, including: Improve decision support & research outcomes with our structured adverse effects data. Avoid life-threatening adverse drug events & improve clinical decision support. Sodium benzoate is commonly produced by the neutralization of sodium hydroxide (NaOH) with benzoic acid (C 6 H 5 COOH), which is itself produced commercially by partial oxidation of toluene with oxygen.. 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